[Effects of inner ear immune responses on auditory function in guinea pigs].

A novel inner ear monitoring system for evaluating ototoxicity of gentamicin eardrops in guinea pigs.

OBJECTIVE/HYPOTHESIS Although most studies have identified damage in the cochlea and semicircular canals as the primary sites of aminoglycoside toxicity, little attention has been devoted to the toxic effects on the otolithic organs. This study aimed to assess the toxic effect of gentamicin eardrops on the inner ear end organs via a novel inner ear monitoring system combined with morphological ...

PURIFICATION AND CHARACTERIZATION OF PROTEIN ANTIGENS ISOLATED FROM MYCOBACTERIUM TUBERCULOSIS (H37Rv STRA IN) AND THEIR EFFECTS ON CELL-MEDIATED IMMUNE RESPONSES IN GUINEA PIGS

Mycobacterium tuberculosis (H37Rv strain) was used in this study. The bacterial cells were disintegrated by sonication. The separation and characterization of the soluble molecules were attempted by various techniques including gel filtration, ion exchange chromatographies and polyacrylamide gel electrophoresis, using SDS and 2ME. Eight protein molecules with molecular weights ranging from...

Auditory function and inner ear pathology in guinea pigs with peripheral nerve demyelination

The audiological or physiological data showed that auditory neuropathy was due to the demylination disease in peripheral nerve, especially in auditory nerve. The aim of this study was to explore the changes of auditory function and auditory nerve pathology through establishing a guinea pig model with demyelinated peripheral nerve. The guinea pig model was established by immunizing guinea pigs w...

Evaluation of Acute Aflatoxicosis on Humoral Immune Response to Foot-and Mouth Disease Vaccination in Guinea Pigs

Effects of an Hypoxia at 5% Oxygen on Global Electrophysiqlogical Responses from Normal and Hmropic Ears of Awake Guinea Pigs

In the continuation of our studies on the involvement of blood supply deficiencies in various experimental pathologies of the inner ear we have conducteaa study on the effects of transient hypoxia on normal and hydropic ears. In the same study we investigated the possible protective effects of an antiischemic drug. All experiments were conducted on awake guinea pigs warranting a normal physiolo...